In Vitro Study of the Action of Carbamide Peroxide 16% on Human Enamel Study of the Effect of Enamel Color Change Produced By The 16% Carbamide Peroxide Gel Prepared In Compounding Pharmacy
Roberto Paulo Correia de Araujo, Danilo Barral de Araujo, Andreia Nobrega Cavalcanti, Elisangela de Jesus Campos, Maria Thereza Barral Araujo

Abstract
Introduction: in recent years, products containing 16% carbamide peroxide intended for self-application tooth whitening have become widely available in the Brazilian market, independent of prescription or professional supervision. Objective: to evaluate, in vitro, the efficacy of human dental enamel whitening by 16% carbamide peroxide prepared in compounding pharmacy compared to the industrially prepared gel. Methodology: based on experimental protocol conducted in vitro, the 16% carbamide peroxide color change of the human dental enamel was determined, through spectrophotometric measurements based on the CIELab system and conducted after 5, 10, 15 and 20 days of application. Results: The result obtained was applied to analysis of variance and Tukey test. Based on the comparisons, the comprehensive evaluation of parameters E, L*, a* and b* demonstrates greater uniformity in the effects produced by the 16% carbamide peroxide of industrial origin compared to the same product prepared in compounding pharmacy. After statistical analysis, the results of this study have proved an effective enamel color change by the carbamide peroxide at 16% concentration, suitable for home use. Conclusion: compounding pharmacy produced carbamide peroxide has a whitening action similar to the one industrially prepared by increasing the brightness and reducing the red and yellow tints of the enamel.

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