In-Vivo Assessment of Some Haematological and Biochemical Parameters in Normal Wistar Rats Treated with Pineapple (Ananas Comosus) Wine
Ajani R.A, Adeniran M.K, Olabinri B.M, Ajani A.J

Abstract
This study revealed the in vivo assessment of some haematological and biochemical parameters in normal Wistar rats treated with Pasteurized fermented pineapple (Ananas comosus) wine with yeast strain Sacharomyces cerevisiae (five days fermentation) at room temperature. The wine was adminisrered orally to sets of normal experimental rats for three months at 0.5ml of pineapple wine/g of body weight in an alternate days with water in between for three consecutive months, and some haematological, histological and biochemical variables before and after the administration of the wine were assessed in the sera of rats. The haematological studies showed that most parameters studied {HB(12.96 ± 2.0-16.52 ± 1.6g/100ml), RBC (5.28 ± 1.0-9.26 ± 1.6 ×106/mm3) and TWBC(3.46 ± 0.6-6.54 ±1.9 × 103/mm3) were significantly higher (P<0.05) only during the second and third month of wine administration. The histological parameters were significantly decreased (P>0.05) for {ALP(101 ± 9.5-91.8 ± 2.4IU/L),AST(68.6 ± 5.0-50.0 ± 3.5IU/L) and ALT(26.4 ± 4.3-13.6 ± 4.4IU/L) and the results of biochemical parameters showed no significant difference (Total Protein, Albumin and Globulin) except for Cholesterol (78.4 ± 4.3 - 67.6 ± 5.6mg/dl-1) and Bilirubin(0.47 ± 0.0 - 0.36 ± 0.2) which showed a significant decrease (P>0.05) at the end of the third month of pineapple wine administration. We concluded that the oral administration of 0.5ml/g body weight of pineapple (Ananas comosus) wine to Wistar rats in alternate days with water for three consecutive months was beneficial in that it increased the haematopoetic effect, served as immune buster as a result of TWBC, and may not lead to the occurrence of liver damage. Therefore, it can be concluded that the moderate consumption of wine may be beneficial to the body.

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